Late to the game here but life’s life. I just installed both Arduino 2.3.6 and the 4.6 update on our old device, the '13MBP and so far ZERO issues. This is a good sign as to the use on our newer device with the M chip. Those of you who hesitated feel free to go for it now.
*M-Chip users you will still see the added stuff your Mac needs to support it all but now it’s mostly automatic. See the Best Practices post covering Rosetta and the Command Line Tools.